{"filing": {"accession": "0001683168-26-007661", "cik": "0001652935", "ticker": "ACTU", "company_name": "ACTUATE THERAPEUTICS, INC.", "form_type": "S-1", "filing_type": "S-1", "filing_date": "2026-10-06", "accepted_datetime": null, "acceptance_datetime": null, "accepted_at": null, "primary_doc_url": "https://www.sec.gov/Archives/edgar/data/1652935/000168316826007661/0001683168-26-007661-index.htm", "filing_url": "https://www.sec.gov/Archives/edgar/data/1652935/000168316826007661/0001683168-26-007661-index.htm", "period_of_report": null}, "html_url": "/api/filings/000168316826007661/stream", "exhibits": [{"exhibit_number": "1.1", "exhibit_type": "1", "description": "Form of Underwriting Agreement between the Registrant and Konik Capital Partners, LLC, a division of T.R. Winston & Company, LLC", "filename": "actuate_ex0101.htm", "edgar_url": "https://www.sec.gov/Archives/edgar/data/1652935/000168316826007661/actuate_ex0101.htm", "category": "debt", "incorporated_by_reference": false}, {"exhibit_number": "4.7", "exhibit_type": "4", "description": "Form of Underwriter\u2019s Warrant", "filename": "actuate_ex0407.htm", "edgar_url": "https://www.sec.gov/Archives/edgar/data/1652935/000168316826007661/actuate_ex0407.htm", "category": "debt", "incorporated_by_reference": false}, {"exhibit_number": "5.1", "exhibit_type": "5", "description": "Opinion of Greenberg Traurig, LLP", "filename": "actuate_ex0501.htm", "edgar_url": "https://www.sec.gov/Archives/edgar/data/1652935/000168316826007661/actuate_ex0501.htm", "category": "other", "incorporated_by_reference": false}, {"exhibit_number": "10.20", "exhibit_type": "10", "description": "Letter Agreement, dated as of October 2, 2026, by and between the Registrant and Bios Partners, L.P.", "filename": "actuate_ex1020.htm", "edgar_url": "https://www.sec.gov/Archives/edgar/data/1652935/000168316826007661/actuate_ex1020.htm", "category": "contracts", "incorporated_by_reference": false}, {"exhibit_number": "10.21", "exhibit_type": "10", "description": "Letter Agreement, dated as of October 2, 2026, by and between the Registrant and Kairos Venture Investments, LLC", "filename": "actuate_ex1021.htm", "edgar_url": "https://www.sec.gov/Archives/edgar/data/1652935/000168316826007661/actuate_ex1021.htm", "category": "contracts", "incorporated_by_reference": false}, {"exhibit_number": "23.1", "exhibit_type": "23", "description": "Consent of Crowe LLP, Independent Registered Public Accounting Firm", "filename": "actuate_ex2301.htm", "edgar_url": "https://www.sec.gov/Archives/edgar/data/1652935/000168316826007661/actuate_ex2301.htm", "category": "other", "incorporated_by_reference": false}, {"exhibit_number": "23.2", "exhibit_type": "23", "description": "Consent of Greenberg Traurig, LLP (included within the opinion filed as Exhibit 5.1)", "filename": "actuate_ex0501.htm", "edgar_url": "https://www.sec.gov/Archives/edgar/data/1652935/000168316826007661/actuate_ex0501.htm", "category": "other", "incorporated_by_reference": false}, {"exhibit_number": "24.1", "exhibit_type": "24", "description": "Power of Attorney (included on the signature page to this registration statement)", "filename": "", "edgar_url": "https://www.sec.gov/Archives/edgar/data/1652935/000168316826007661/actuate_s1.htm#a_018", "category": "other", "incorporated_by_reference": false}, {"exhibit_number": "3.1", "exhibit_type": "3", "description": "Sixth Amended and Restated Certificate of Incorporation of the Registrant (incorporated by reference to Registrant\u2019s Current Report on Form 8-K as filed on August 14, 2024)", "filename": "", "edgar_url": "https://www.sec.gov/Archives/edgar/data/1652935/000110465924089693/tm2419022d1_ex3-1.htm", "category": "incorporation", "incorporated_by_reference": true}, {"exhibit_number": "3.2", "exhibit_type": "3", "description": "Amended and Restated Bylaws of the Registrant (incorporated by reference to Registrant\u2019s Current Report on Form 8-K as filed on August 14, 2024)", "filename": "", "edgar_url": "https://www.sec.gov/Archives/edgar/data/1652935/000110465924089693/tm2419022d1_ex3-2.htm", "category": "incorporation", "incorporated_by_reference": true}, {"exhibit_number": "4.1", "exhibit_type": "4", "description": "Form of Common Stock Certificate of the Registrant (incorporated by reference to Registrant\u2019s Registration Statement on Form S-1/A, filed with the SEC on June 11, 2024)", "filename": "", "edgar_url": "https://www.sec.gov/Archives/edgar/data/1652935/000110465924070185/tm247121d16_ex4-1.htm", "category": "other", "incorporated_by_reference": true}, {"exhibit_number": "4.2", "exhibit_type": "4", "description": "Fourth Amended and Restated Investors\u2019 Rights Agreement by and between the Registrant and certain of its stockholders, dated November 30, 2022 (incorporated by reference to Registrant\u2019s Registration Statement on Form S-1, filed with the SEC on May 24, 2024)", "filename": "", "edgar_url": "https://www.sec.gov/Archives/edgar/data/1652935/000110465924065172/tm247121d13_ex4-2.htm", "category": "debt", "incorporated_by_reference": true}, {"exhibit_number": "4.3", "exhibit_type": "4", "description": "Form of Representative Warrant issued to Underwriter under IPO (incorporated by reference to Registrant\u2019s Registration Statement on Form S-1/A, filed with the SEC on June 11, 2024)", "filename": "", "edgar_url": "https://www.sec.gov/Archives/edgar/data/1652935/000110465924070185/tm247121d16_ex4-3.htm", "category": "debt", "incorporated_by_reference": true}, {"exhibit_number": "4.4", "exhibit_type": "4", "description": "Form of Second Amended and Restated Warrant issued to holders of Convertible Redeemable Preferred Stock (incorporated by reference to Registrant\u2019s Registration Statement on Form S-1/A, filed with the SEC on June 11, 2024)", "filename": "", "edgar_url": "https://www.sec.gov/Archives/edgar/data/1652935/000110465924070185/tm247121d16_ex4-4.htm", "category": "debt", "incorporated_by_reference": true}, {"exhibit_number": "4.5", "exhibit_type": "4", "description": "Description of the Registrant\u2019s Securities Registered Pursuant to Section 12 of the Securities Exchange Act of 1934 (incorporated by reference to Registrant\u2019s Annual Report on Form 10-K, filed with the SEC on March 13, 2025)", "filename": "", "edgar_url": "https://www.sec.gov/Archives/edgar/data/1652935/000168316825001581/actuate_ex0405.htm", "category": "debt", "incorporated_by_reference": true}, {"exhibit_number": "4.6", "exhibit_type": "4", "description": "Form of Warrant, dated June 25, 2025, by and among Registrant and each of the purchasers party thereto under the Securities Purchase Agreement (incorporated by reference to Registrant\u2019s Current Report on Form 8-K as filed on June 26, 2025)", "filename": "", "edgar_url": "https://www.sec.gov/Archives/edgar/data/1652935/000168316825004766/actuate_ex0401.htm", "category": "debt", "incorporated_by_reference": true}, {"exhibit_number": "10.3", "exhibit_type": "10", "description": "Actuate Therapeutics, Inc. 2015 Equity Incentive Plan, as amended, and form of grant agreements thereunder (incorporated by reference to Registrant\u2019s Registration Statement on Form S-1, filed with the SEC on May 24, 2024)", "filename": "", "edgar_url": "https://www.sec.gov/Archives/edgar/data/1652935/000110465924065172/tm247121d13_ex10-1.htm", "category": "contracts", "incorporated_by_reference": true}, {"exhibit_number": "10.4", "exhibit_type": "10", "description": "Actuate Therapeutics, Inc. 2024 Equity Incentive Plan (incorporated by reference to Registrant\u2019s Registration Statement on Form S-1, filed with the SEC on May 24, 2024)", "filename": "", "edgar_url": "https://www.sec.gov/Archives/edgar/data/1652935/000110465924065172/tm247121d13_ex10-2.htm", "category": "contracts", "incorporated_by_reference": true}, {"exhibit_number": "10.5", "exhibit_type": "10", "description": "Form of Stock Option Agreement under the Actuate Therapeutics, Inc. 2024 Stock Incentive Plan (incorporated by reference to Registrant\u2019s Registration Statement on Form S-1/A, filed with the SEC on June 11, 2024)", "filename": "", "edgar_url": "https://www.sec.gov/Archives/edgar/data/1652935/000110465924070185/tm247121d16_ex10-13.htm", "category": "contracts", "incorporated_by_reference": true}, {"exhibit_number": "10.6", "exhibit_type": "10", "description": "Form of Restricted Stock Unit Agreement under the Actuate Therapeutics, Inc. 2024 Stock Incentive Plan (incorporated by reference to Registrant\u2019s Registration Statement on Form S-1/A, filed with the SEC on June 11, 2024)", "filename": "", "edgar_url": "https://www.sec.gov/Archives/edgar/data/1652935/000110465924070185/tm247121d16_ex10-14.htm", "category": "contracts", "incorporated_by_reference": true}, {"exhibit_number": "10.7", "exhibit_type": "10", "description": "Non-Employee Director Compensation Policy (incorporated by reference to Registrant\u2019s Registration Statement on Form S-1/A, filed with the SEC on June 21, 2024)", "filename": "", "edgar_url": "https://www.sec.gov/Archives/edgar/data/1652935/000110465924073848/tm247121d19_ex10-3.htm", "category": "contracts", "incorporated_by_reference": true}, {"exhibit_number": "10.8", "exhibit_type": "10", "description": "Employment Agreement, effective April 15, 2015 and as amended on each of February 5, 2016, September 28, 2017, September 23, 2018, January 29, 2019, August 1, 2022, January 27, 2023 December 12, 2023 and May 9, 2024, between Daniel Schmitt, and the Registrant (incorporated by reference to Registrant\u2019s Registration Statement on Form S-1, filed with the SEC on May 24, 2024)", "filename": "", "edgar_url": "https://www.sec.gov/Archives/edgar/data/1652935/000110465924065172/tm247121d13_ex10-6.htm", "category": "contracts", "incorporated_by_reference": true}, {"exhibit_number": "10.9", "exhibit_type": "10", "description": "Employment Agreement, effective June 1, 2022, between Andrew P. Mazar, Ph.D. and the Registrant (incorporated by reference to Registrant\u2019s Registration Statement on Form S-1, filed with the SEC on May 24, 2024)", "filename": "", "edgar_url": "https://www.sec.gov/Archives/edgar/data/1652935/000110465924065172/tm247121d13_ex10-7.htm", "category": "contracts", "incorporated_by_reference": true}, {"exhibit_number": "10.10", "exhibit_type": "10", "description": "Employment Agreement, effective June 1, 2024, between Paul Lytle, and the Registrant (incorporated by reference to Registrant\u2019s Registration Statement on Form S-1, filed with the SEC on May 24, 2024)", "filename": "", "edgar_url": "https://www.sec.gov/Archives/edgar/data/1652935/000110465924065172/tm247121d13_ex10-9.htm", "category": "contracts", "incorporated_by_reference": true}, {"exhibit_number": "10.11", "exhibit_type": "10", "description": "Form of Indemnification Agreement for Directors and Officers (incorporated by reference to Registrant\u2019s Registration Statement on Form S-1, filed with the SEC on May 24, 2024)", "filename": "", "edgar_url": "https://www.sec.gov/Archives/edgar/data/1652935/000110465924065172/tm247121d13_ex10-10.htm", "category": "contracts", "incorporated_by_reference": true}, {"exhibit_number": "10.12", "exhibit_type": "10", "description": "Tenth Amendment to Employment Agreement by and between Daniel Schmitt and the Registrant dated March 11, 2025 (incorporated by reference to Registrant\u2019s Quarterly Report on Form 10-Q, filed with the SEC on May 15, 2025)", "filename": "", "edgar_url": "https://www.sec.gov/Archives/edgar/data/1652935/000168316825003705/actuate_ex1003.htm", "category": "contracts", "incorporated_by_reference": true}, {"exhibit_number": "10.13", "exhibit_type": "10", "description": "First Amendment to Employment Agreement by and between Andrew P. Mazar, Ph.D. and the Registrant dated March 11, 2025 (incorporated by reference to Registrant\u2019s Quarterly Report on Form 10-Q, filed with the SEC on May 15, 2025)", "filename": "", "edgar_url": "https://www.sec.gov/Archives/edgar/data/1652935/000168316825003705/actuate_ex1004.htm", "category": "contracts", "incorporated_by_reference": true}, {"exhibit_number": "10.14", "exhibit_type": "10", "description": "First Amendment to Employment Agreement by and between Paul Lytle and the Registrant dated March 11, 2025 (incorporated by reference to Registrant\u2019s Quarterly Report on Form 10-Q, filed with the SEC on May 15, 2025)", "filename": "", "edgar_url": "https://www.sec.gov/Archives/edgar/data/1652935/000168316825003705/actuate_ex1005.htm", "category": "contracts", "incorporated_by_reference": true}, {"exhibit_number": "10.15", "exhibit_type": "10", "description": "Securities Purchase Agreement, dated March 27, 2025, by and between Registrant and B. Riley Principal Capital II, LLC (incorporated by reference to Registrant\u2019s Current Report on Form 8-K as filed on March 28, 2025)", "filename": "", "edgar_url": "https://www.sec.gov/Archives/edgar/data/1652935/000168316825001945/actuate_ex1001.htm", "category": "contracts", "incorporated_by_reference": true}, {"exhibit_number": "10.16", "exhibit_type": "10", "description": "Registration Rights Agreement, dated March 27, 2025, by and between Registrant and B. Riley Principal Capital II, LLC (incorporated by reference to Registrant\u2019s Current Report on Form 8-K as filed on March 28, 2025)", "filename": "", "edgar_url": "https://www.sec.gov/Archives/edgar/data/1652935/000168316825001945/actuate_ex1002.htm", "category": "debt", "incorporated_by_reference": true}, {"exhibit_number": "10.17", "exhibit_type": "10", "description": "Form of Securities Purchase Agreement, dated June 25, 2025, by and among Registrant and each of the purchasers party thereto (incorporated by reference to Registrant\u2019s Current Report on Form 8-K as filed on June 26, 2025)", "filename": "", "edgar_url": "https://www.sec.gov/Archives/edgar/data/1652935/000168316825004766/actuate_ex1001.htm", "category": "contracts", "incorporated_by_reference": true}, {"exhibit_number": "10.18", "exhibit_type": "10", "description": "Form of Registration Rights Agreement, dated June 25, 2025, by and among Registrant and each of the purchasers party thereto (incorporated by reference to Registrant\u2019s Current Report on Form 8-K as filed on June 26, 2025)", "filename": "", "edgar_url": "https://www.sec.gov/Archives/edgar/data/1652935/000168316825004766/actuate_ex1002.htm", "category": "debt", "incorporated_by_reference": true}, {"exhibit_number": "10.19", "exhibit_type": "10", "description": "At the Market Issuance Sales Agreement dated as of November 28, 2025 between Registrant, on the one hand, and B. Riley Securities, Inc. and Craig-Hallum Capital Group LLC, on the other (incorporated by reference to Registrant\u2019s Current Report on Form 8-K as filed on November 28, 2025)", "filename": "", "edgar_url": "https://www.sec.gov/Archives/edgar/data/1652935/000168316825008732/actuate_ex0101.htm", "category": "contracts", "incorporated_by_reference": true}, {"exhibit_number": "19.1", "exhibit_type": "19", "description": "Insider Trading Policy (incorporated by reference to Registrant\u2019s Annual Report on Form 10-K, filed with the SEC on March 13, 2025)", "filename": "", "edgar_url": "https://www.sec.gov/Archives/edgar/data/1652935/000168316825001581/actuate_ex1901.htm", "category": "other", "incorporated_by_reference": true}, {"exhibit_number": "21.1", "exhibit_type": "21", "description": "Subsidiaries of the Registrant (incorporated by reference to Registrant\u2019s Annual Report on Form 10-K, filed with the SEC on March 26, 2026)", "filename": "", "edgar_url": "https://www.sec.gov/Archives/edgar/data/1652935/000168316826002257/actuate_ex2101.htm", "category": "other", "incorporated_by_reference": true}], "sections": [{"section_name": "part_1", "section_title": "Part I", "start_position": 27563, "end_position": 95035}, {"section_name": "part_2", "section_title": "Part II", "start_position": 95035, "end_position": 121986}], "tables": [{"table_index": 0, "table_type": "text", "caption": null, "header_text": "Delaware873147-3044785"}, {"table_index": 2, "table_type": "text", "caption": null, "header_text": "Large accelerated filer \u2610Accelerated filer \u2610"}, {"table_index": 5, "table_type": "financial", "caption": null, "header_text": "Per ShareTotal"}, {"table_index": 8, "table_type": "text", "caption": null, "header_text": "ABOUT THIS PROSPECTUSii"}, {"table_index": 16, "table_type": "financial", "caption": null, "header_text": "Common stock offered by us50,000,000 shares of our common stock (57,500,000 shares if the underwriter exercises its over-allotment option in full)."}, {"table_index": 18, "table_type": "text", "caption": null, "header_text": "\u00b72,755,836 shares of our common stock issuable upon the exercise of stock options outstanding as of June 30, 2026, at a weighted average exercise price of $5.14 per share;"}, {"table_index": 69, "table_type": "text", "caption": null, "header_text": "Assumed public offering price per share of common stock$0.819"}, {"table_index": 76, "table_type": "text", "caption": null, "header_text": "\u00b73,000,000 additional shares of our common stock reserved for issuance upon exercise of warrants, with an exercise price of $ per share, which will be issued to the Bios Entities at the close of this "}, {"table_index": 78, "table_type": "text", "caption": null, "header_text": "UnderwriterNumber of Shares"}, {"table_index": 79, "table_type": "financial", "caption": null, "header_text": "Total"}, {"table_index": 83, "table_type": "text", "caption": null, "header_text": "\u00b7Short positions involve\nsales by the underwriters of shares in excess of the number of shares the underwriters are obligated to purchase, which creates a syndicate\nshort position. The short position "}, {"table_index": 85, "table_type": "text", "caption": null, "header_text": "\u00b7the history and prospects for the industry in\nwhich we compete;"}, {"table_index": 89, "table_type": "text", "caption": null, "header_text": "\u00b7our Annual Report onForm 10-Kfor the fiscal year ended December 31, 2025, filed with the SEC on March 26, 2026;"}, {"table_index": 94, "table_type": "financial", "caption": null, "header_text": "ItemAmount to be paid"}, {"table_index": 97, "table_type": "exhibit_index", "caption": null, "header_text": "Exhibit NumberDescription of Document"}, {"table_index": 99, "table_type": "text", "caption": null, "header_text": "4.6Form of Warrant, dated June 25, 2025, by and among Registrant and each of the purchasers party thereto under the Securities Purchase Agreement(incorporated by reference to Registrant\u2019s Current Repo"}, {"table_index": 101, "table_type": "exhibit_index", "caption": null, "header_text": "21.1Subsidiaries of the Registrant(incorporated by reference to Registrant\u2019s Annual Report on Form 10-K, filed with the SEC on March 26, 2026)"}, {"table_index": 102, "table_type": "exhibit_index", "caption": null, "header_text": "*Filed herewith."}, {"table_index": 114, "table_type": "text", "caption": null, "header_text": "ACTUATE THERAPEUTICS, INC."}, {"table_index": 115, "table_type": "text", "caption": null, "header_text": "NamePositionDate"}], "exhibits_pending": false, "cdn_html": true, "response_time_ms": 39}